Super CitriMax® Shown Safe in Long-Term Reproductive and Teratogenicity Studies
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Super CitriMax® is a patented calcium/potassium salt of (–)-hydroxycitric acid (HCA-SX) extracted from the dried fruit rind of the plant Garcinia cambogia, which has been used in southeast Asia for centuries to make meals more filling. Super CitriMax has been shown to promote fat oxidation, inhibit fat production, suppress appetite and reduce body weight 3-times greater than diet and exercise alone. A broad spectrum of previous studies, including several human clinical trials and gene array analyses, have also shown the ingredient to be extremely safe and non-toxic. In this study, researchers looked at the reproductive and teratogenicity (developmental) safety of Super CitriMax. Studying two generations of Sprague-Dawley rats, researchers analyzed the reproductive systems of both males and females, the postnatal maturation and reproductive capacity of their offspring, and the possible cumulative effects through multiple generations. Animals were fed either none or one of three dose levels of Super CitriMax at 1000 ppm, 3000 ppm and 10,000 ppm, approximately equivalent to the dose levels of 100 mg, 300 mg or 1000 mg/kg/day respectively, for 10 weeks prior to mating, during mating and, for females, through gestation and lactation, across two generations. Researchers found no reproductive or developmental toxicity in the parents or offspring, respectively. No adverse effects on reproductive performance were observed as evaluated by sexual maturity, fertility and mating, gestation, parturition, litter properties, lactation or development of offspring. Super CitriMax, at these high dose levels, did not induce any systemic toxicity in the parental rats and their offspring. Neither sperm motility nor sperm count were negatively affected in either the parental groups or the first generation groups. No teratogenicity (malformations) was observed. These findings add to the extensive body of evidence showing the long-term safety of Super CitriMax.
Source: D. Bagchi, Misleading Toxicity Reports on Safety of Weight Reducing Dietary Supplements: Example of
Garcinia Cambogia Extract—
Annual Meeting of the Society of Toxicology, Vol. 96, No. 1, Abs. 2173, Pg. 448, March 2007.
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